• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    Concentric flow-focusing encapsulation devices and methods for the production of microencapsulated drops of a first material in the nucleus surrounded by a second material in the cortex that include the evaluation of dimensionless fluid-dynamic parameters that refer to the characteristics of the droplets that are produce the parameters are specifically related to characteristics such as homogenous or non-homogeneous break modes of the concentric drops, density of distribution of droplet sizes and qualities such as the monodispersion of the droplets produced. By identifying the control parameters in the specific regions, the control variables can be selected to produce droplets or particles with the desired qualities. (Machine-translation by Google Translate, not legally binding)
    公开号:ES2606957A1
    申请号:ES201531376
    申请日:2015-09-28
    公开日:2017-03-28
    发明作者:Inmaculada MUÑOZ；Jerónimo ESCUDERO；Gloria JURADO；Antonio SERRANO；Sandra VELÁZQUEZ；María FLORES MOSQUERA；Alfonso Miguel Gañán-Calvo
    申请人:Ingeniatrics Tecnologias S L；Ingeniatrics Tecnologias Sl；Universidad de Sevilla；
    IPC主号:
    专利说明:

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    General for concentric flow focusing encapsulation of a first material (or core) in a second material (or crust) using a pressurized gas (or focusing fluid) to form a drop includes at least thirteen dimensional physical variables, including the following:
    {ρ, ρ, ρ, µ, µ, µ, σ, σ, σ, Q, Q, ΔP, D}
    12312312 312
    5 where each variable has the following value:
    ρ1: density of the first material (core) ρ 2: density of the second material (crust) ρ3: density of the third material (focusing fluid, gas) µ1: viscosity of the first material (core) µ 2: viscosity of the second material (crust) µ3: viscosity of the third material (focusing fluid, gas) σ 1: surface tension between the first material (core) and the second material (crust) σ 2: surface tension between the second material (crust) and the third material (focusing fluid , gas) σ 3: surface tension between the first material (core) and the third material (focusing fluid, gas) Q1: Flow rate of the first material (core, liquid) Q2: Flow rate of the second material (crust, liquid) ΔP: difference of the pressure of the third material (focusing fluid, gas) through the outlet hole
    D: diameter of the outlet opening of the pressurized chamber
    The number of control variables in the parametric space necessary to investigate the dispersion characteristics of the concentric flow focusing microencapsulation can be reduced based on certain assumptions associated with the desired flow regime. First, it is known in the art that the diameter of the outlet orifice 18 of the pressurized chamber has a negligible influence on the flow dispersion properties of a laminar capillary microchorr. Second, the relative difference between the densities ρ1 and ρ2 is very small compared to the value of the densities themselves, and these values can approximate
    15 constant. Similarly, the third material 38 introduced through the pressurized chamber is typically a gas such as air having a constant density (ρ3).
    9
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    The present invention provides a method for producing encapsulated drops of a first material as a core surrounded by a second material as a crust. The method includes the steps of (a) providing an encapsulation apparatus that includes a first channel with an exit opening, a second channel with an exit opening arranged around the
    5 exit opening of the first channel, and a pressurized chamber at least partially surrounding the exit openings of the first channel and the second channel, where the pressurized chamber includes an exit hole of the pressurized chamber following the exit openings of the first and second channel; (b) identify a first group of control parameters associated with undesirable flow regimes in the regions:
    10 (i) Re2We1 1/4 <1.2, or
    (ii) Re12Re2 <10 and Re2We2 <3, or
    (iii) Re2We1 / We2 <1;
    (c) select the control variables based at least in part on the group of control variables identified in step (b); (d) introducing a first material in the first channel, a second material in the second channel, and a third material in the pressurized chamber so that the first and second material form a microbead that extends into the exit orifice of the pressurized chamber; and (e) forming a plurality of microencapsulated drops of the first material surrounded by the second material when the third material exits through the outlet opening of the pressurized chamber. In additional applications, the present invention provides a
    20 dispersion of drops or encapsulated particles produced in accordance with the method described above.
    In further embodiments, the present invention shows a method of producing encapsulated droplets that includes the steps of: (a) providing an encapsulation apparatus that includes a first channel with an exit opening, a second channel with an exit opening arranged around of the exit opening of the first channel, and a pressurized chamber at least partially surrounding the exit openings of the first channel and the second channel, where the pressurized chamber includes an exit hole of the pressurized chamber following the exit openings of the first and second channel; (b) identify a first
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    权利要求:
    Claims (1)
    [1]
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    类似技术:
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    同族专利:
    公开号 | 公开日
    ES2606957B1|2018-01-15|
    DK3356024T3|2022-02-14|
    EP3356024A1|2018-08-08|
    EP3356024B1|2021-11-03|
    WO2017056019A1|2017-04-06|
    US10730029B2|2020-08-04|
    US20180272306A1|2018-09-27|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    WO1999030832A1|1997-12-17|1999-06-24|Universidad De Sevilla|Stabilized capillary microjet and devices and methods for producing same|
    US6248378B1|1998-12-16|2001-06-19|Universidad De Sevilla|Enhanced food products|
    EP1424346A1|2001-07-31|2004-06-02|Mitsubishi Chemical Corporation|Method of polymerization and nozzle for use in the polymerization method|
    US6187214B1|1996-05-13|2001-02-13|Universidad De Seville|Method and device for production of components for microfabrication|
    EP1037858A1|1997-12-17|2000-09-27|Universidad de Sevilla|Device and method for creating spherical particles of uniform size|
    US6450189B1|1998-11-13|2002-09-17|Universidad De Sevilla|Method and device for production of components for microfabrication|
    WO1999030833A1|1997-12-17|1999-06-24|Universidad De Sevilla|Device and method for creating dry particles|
    ES2273572B1|2005-05-04|2008-04-01|Universidad De Sevilla|MICRO AND NANOMETRIC SIZE PARTICLE PREPARATION PROCEDURE WITH LABIL PRODUCTS AND PARTICLES OBTAINED.|ES2663217B1|2016-10-10|2019-02-07|Ingeniatrics Tecnologias S L|Apparatus and method for mixing at least two liquids|
    法律状态:
    2018-01-15| FG2A| Definitive protection|Ref document number: 2606957 Country of ref document: ES Kind code of ref document: B1 Effective date: 20180115 |
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    优先权:
    申请号 | 申请日 | 专利标题
    ES201531376A|ES2606957B1|2015-09-28|2015-09-28|Devices and methods for concentric capillary based microencapsulation|ES201531376A| ES2606957B1|2015-09-28|2015-09-28|Devices and methods for concentric capillary based microencapsulation|
    US15/761,020| US10730029B2|2015-09-28|2016-09-28|Concentric capillary microencapsulation devices and methods|
    DK16778119.4T| DK3356024T3|2015-09-28|2016-09-28|PROCEDURE FOR THE PREPARATION OF ENCLOSURED SMALL DROPS WITH A CONCENTRIC CAPILLARY MICRO-ENCAPE DEVICE|
    EP16778119.4A| EP3356024B1|2015-09-28|2016-09-28|Method of producing encapsulated droplets with a concentric capillary microencapsulation device|
    PCT/IB2016/055804| WO2017056019A1|2015-09-28|2016-09-28|Concentric capillary microencapsulation devices and methods|
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